2NV7

Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555

2NV7 の概要

• エントリーDOI: 10.2210/pdb2nv7/pdb
• 分子名称: Estrogen receptor beta, Nuclear receptor coactivator 1, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME, ... (4 entities in total)
• 機能のキーワード: estrogen receptor, estrogen receptor beta, er-beta, er, estrogen, nuclear receptor, transcription factor, agonist, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q92731; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56683.31

構造登録者

Mewshaw, R.E.,Bowen, M.S.,Harris, H.A.,Xu, Z.B.,Manas, E.S.,Cohn, S.T.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2006-11-10, 公開日: 2007-08-21, 最終更新日: 2024-04-03)

• 主引用文献: Mewshaw, R.E.,Bowen, S.M.,Harris, H.A.,Xu, Z.B.,Manas, E.S.,Cohn, S.T.; ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives.; Bioorg.Med.Chem.Lett., 17:902-906, 2007; PubMed: 17188490; DOI: 10.1016/j.bmcl.2006.11.066

実験手法

X-RAY DIFFRACTION (2.1 Å)