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2NPU

The solution structure of the rapamycin-binding domain of mTOR (FRB)

Summary for 2NPU
Entry DOI10.2210/pdb2npu/pdb
NMR InformationBMRB: 6760
DescriptorFKBP12-rapamycin complex-associated protein (1 entity in total)
Functional Keywordsfour-helix bundle, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight15361.41
Authors
Veverka, V.,Crabbe, T.,Bird, I.,Lennie, G.,Muskett, F.W.,Taylor, R.J.,Carr, M.D. (deposition date: 2006-10-30, release date: 2007-09-18, Last modification date: 2023-06-14)
Primary citationVeverka, V.,Crabbe, T.,Bird, I.,Lennie, G.,Muskett, F.W.,Taylor, R.J.,Carr, M.D.
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27:585-595, 2008
Cited by
PubMed: 17684489
DOI: 10.1038/sj.onc.1210693
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

217705

数据于2024-03-27公开中

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