2NPU

The solution structure of the rapamycin-binding domain of mTOR (FRB)

2NPU の概要

• エントリーDOI: 10.2210/pdb2npu/pdb
• NMR情報: BMRB: 6760
• 分子名称: FKBP12-rapamycin complex-associated protein (1 entity in total)
• 機能のキーワード: four-helix bundle, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15361.41

構造登録者

Veverka, V.,Crabbe, T.,Bird, I.,Lennie, G.,Muskett, F.W.,Taylor, R.J.,Carr, M.D. (登録日: 2006-10-30, 公開日: 2007-09-18, 最終更新日: 2024-05-15)

• 主引用文献: Veverka, V.,Crabbe, T.,Bird, I.,Lennie, G.,Muskett, F.W.,Taylor, R.J.,Carr, M.D.; Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.; Oncogene, 27:585-595, 2008; PubMed: 17684489; DOI: 10.1038/sj.onc.1210693

実験手法