2NO3
Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
Summary for 2NO3
Entry DOI | 10.2210/pdb2no3/pdb |
Related | 2g01 2gmx 2h96 |
Descriptor | Mitogen-activated protein kinase 8, C-JUN-AMINO-TERMINAL KINASE-INTERACTING protein 1, SULFATE ION, ... (4 entities in total) |
Functional Keywords | jnk1, c-jun n-terminal kinase, jnk1 inhibitors, anilinopyrimidines jnk1 inhibitors, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : P45983 |
Total number of polymer chains | 4 |
Total formula weight | 89557.26 |
Authors | Abad-Zapatero, C. (deposition date: 2006-10-24, release date: 2007-04-17, Last modification date: 2023-08-30) |
Primary citation | Liu, M.,Wang, S.,Clampit, J.E.,Gum, R.J.,Haasch, D.L.,Rondinone, C.M.,Trevillyan, J.M.,Abad-Zapatero, C.,Fry, E.H.,Sham, H.L.,Liu, G. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg.Med.Chem.Lett., 17:668-672, 2007 Cited by PubMed: 17107797DOI: 10.1016/j.bmcl.2006.10.093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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