2NNQ

Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid

2NNQ の概要

• エントリーDOI: 10.2210/pdb2nnq/pdb
• 分子名称: Fatty acid-binding protein, adipocyte, SULFATE ION, ((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: transport, lipid-binding, lipid transport
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15090
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15275.38

構造登録者

Jacobson, B.L. (登録日: 2006-10-24, 公開日: 2007-06-12, 最終更新日: 2024-04-03)

主引用文献

Sulsky, R.,Magnin, D.R.,Huang, Y.,Simpkins, L.,Taunk, P.,Patel, M.,Zhu, Y.,Stouch, T.R.,Bassolino-Klimas, D.,Parker, R.,Harrity, T.,Stoffel, R.,Taylor, D.S.,Lavoie, T.B.,Kish, K.,Jacobson, B.L.,Sheriff, S.,Adam, L.P.,Ewing, W.R.,Robl, J.A.
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).
Bioorg.Med.Chem.Lett., 17:3511-3515, 2007

PubMed Abstract: Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. In addition a new radio-ligand to determine binding against the three fatty acid binding proteins was also synthesized.

PubMed: 17502136
DOI: 10.1016/j.bmcl.2006.12.044

実験手法

X-RAY DIFFRACTION (1.8 Å)