2NMY

Crystal structure analysis of HIV-1 protease mutant V82A with a inhibitor saquinavir

Summary for 2NMY

• Entry DOI: 10.2210/pdb2nmy/pdb
• Related: 2NMW 2NMZ 2NNK 2NNP
• Related PRD ID: PRD_000454
• Descriptor: PROTEASE, CHLORIDE ION, SODIUM ION, ... (6 entities in total)
• Functional Keywords: hiv-1 protease, mutant, v82a, dimer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587
• Total number of polymer chains: 2
• Total formula weight: 22286.05

Authors

Tie, Y.,Kovalevsky, A.Y.,Boross, P.,Wang, Y.F.,Ghosh, A.K.,Tozser, J.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-10-23, release date: 2007-03-13, Last modification date: 2023-12-27)

• Primary citation: Tie, Y.,Kovalevsky, A.Y.,Boross, P.,Wang, Y.F.,Ghosh, A.K.,Tozser, J.,Harrison, R.W.,Weber, I.T.; Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.; Proteins, 67:232-242, 2007; PubMed: 17243183; DOI: 10.1002/prot.21304

Experimental method

X-RAY DIFFRACTION (1.1 Å)