2NLA

Crystal structure of the Mcl-1:mNoxaB BH3 complex

Summary for 2NLA

Entry DOI	10.2210/pdb2nla/pdb
Related	1WSX 2NL9
Descriptor	FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Phorbol-12-myristate-13-acetate-induced protein 1 (3 entities in total)
Functional Keywords	apoptosis, bcl-2, mcl-1, noxa
Biological source	Mus musculus (mouse) More
Cellular location	Membrane ; Single-pass membrane protein : Q07820 Mitochondrion : Q9JM54
Total number of polymer chains	2
Total formula weight	20829.65
Authors	Czabotar, P.E.,Colman, P.M. (deposition date: 2006-10-19, release date: 2007-03-27, Last modification date: 2023-12-27)
Primary citation	Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA, 104:6217-6222, 2007 Cited by PubMed: 17389404 DOI: 10.1073/pnas.0701297104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation