2NBP

Solution structure of the T119M variant of transthyretin in its monomeric state

2NBP の概要

• エントリーDOI: 10.2210/pdb2nbp/pdb
• 関連するPDBエントリー: 2NBO
• NMR情報: BMRB: 25987
• 分子名称: Transthyretin (1 entity in total)
• 機能のキーワード: transthyretin, amyloid, aggregation, monomer, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13809.51

構造登録者

Kim, J.,Oroz, J.,Zweckstetter, M. (登録日: 2016-03-09, 公開日: 2017-05-10, 最終更新日: 2024-05-15)

主引用文献

Kim, J.H.,Oroz, J.,Zweckstetter, M.
Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation.
Angew. Chem. Int. Ed. Engl., 55:16168-16171, 2016

PubMed Abstract: Mutations in the protein transthyretin can cause as well as protect individuals from transthyretin amyloidosis, an incurable fatal inherited disease. Little is known, however, about the structural basis of pathogenic and clinically protective transthyretin mutants. Here we determined the solution structure of a transthyretin monomer that carries the clinically important T119M mutation. The structure displays a non-native arrangement that is distinct from all known structures of transthyretin and highlights the importance of high-resolution studies in solution for understanding molecular processes that lead to amyloid diseases.

PubMed: 27885756
DOI: 10.1002/anie.201608516

実験手法

SOLUTION NMR