2N7T

NMR structure of Peptide PG-992 in DPC micelles

2N7T の概要

• エントリーDOI: 10.2210/pdb2n7t/pdb
• NMR情報: BMRB: 25820
• 分子名称: Peptide PG-992 (1 entity in total)
• 機能のキーワード: de novo protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1223.45

構造登録者

Carotenuto, A.,Merlino, F.,Chai, M.,Brancaccio, D.,Yousif, A.,Novellino, E.,Hruby, V.,Grieco, P. (登録日: 2015-09-17, 公開日: 2015-12-16, 最終更新日: 2024-11-27)

主引用文献

Carotenuto, A.,Merlino, F.,Cai, M.,Brancaccio, D.,Yousif, A.M.,Novellino, E.,Hruby, V.J.,Grieco, P.
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.
J.Med.Chem., 58:9773-9778, 2015

PubMed Abstract: The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.

PubMed: 26599352
DOI: 10.1021/acs.jmedchem.5b01285

実験手法

SOLUTION NMR