2N54

Solution structure of a disulfide stabilized XCL1 dimer

Summary for 2N54

• Entry DOI: 10.2210/pdb2n54/pdb
• NMR Information: BMRB: 25693
• Descriptor: Lymphotactin (1 entity in total)
• Functional Keywords: xcl1, dimer, chemokine, metamorphic, gag-binding, hiv-1 inhibition, lymphotactin, atac, cytokine
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P47992
• Total number of polymer chains: 2
• Total formula weight: 20701.84

Authors

Tyler, R.C.,Tuinstra, R.L.,Peterson, F.F.,Volkman, B.F. (deposition date: 2015-07-07, release date: 2015-10-07, Last modification date: 2023-06-14)

• Primary citation: Fox, J.C.,Tyler, R.C.,Guzzo, C.,Tuinstra, R.L.,Peterson, F.C.,Lusso, P.,Volkman, B.F.; Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation.; Acs Chem.Biol., 10:2580-2588, 2015; PubMed: 26302421; DOI: 10.1021/acschembio.5b00542

Experimental method

SOLUTION NMR