2N26

Solution structure of Miz-1 zinc fingers 3 and 4

2N26 の概要

• エントリーDOI: 10.2210/pdb2n26/pdb
• 関連するPDBエントリー: 2N25
• NMR情報: BMRB: 25587
• 分子名称: Zinc finger and BTB domain-containing protein 17, ZINC ION (2 entities in total)
• 機能のキーワード: miz-1, zbtb17, c2h2 zinc finger, dna binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q13105
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12933.58

構造登録者

Bedard, M.,Lavigne, P. (登録日: 2015-04-28, 公開日: 2015-06-17, 最終更新日: 2024-05-01)

主引用文献

Tremblay, C.,Bedard, M.,Bonin, M.A.,Lavigne, P.
Solution structure of the 13th C2H2 Zinc Finger of Miz-1.
Biochem.Biophys.Res.Commun., 473:471-475, 2016

PubMed Abstract: Miz-1 is a BTB/POZ transcription factor that contains 13C2H2 Zinc Finger domains (ZF). Miz-1 transactivates and represses the transcription of a myriad of genes involved in many aspects of the biology of the cell. The detailed molecular interactions through which Miz-1 controls transcription, including its specific DNA binding via its ZF domains, remain to be understood and documented. In our effort to shed light into the structural biology of Miz-1, we have undertaken the determination of the structure of all its ZF and the characterization of their interactions with cognate DNA. The structure of ZF 1 to 10 have already been solved and characterized. Here, we present the structure of the synthetic Miz-1 ZF13 determined by 2D (1)H-(1)H NMR.

PubMed: 26972249
DOI: 10.1016/j.bbrc.2016.03.034

実験手法

SOLUTION NMR