2MY9

Solution structure of N-terminal domain of human TIG3

2MY9 の概要

• エントリーDOI: 10.2210/pdb2my9/pdb
• 関連するPDBエントリー: 2lkt
• NMR情報: BMRB: 25448
• 分子名称: Retinoic acid receptor responder protein 3 (1 entity in total)
• 機能のキーワード: tig3, h-rev107 family, nlpc/p60, phospholipase, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane ; Single-pass membrane protein : Q9UL19
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14050.89

構造登録者

Wei, H.,Wang, L.,Xia, B. (登録日: 2015-01-21, 公開日: 2015-04-15, 最終更新日: 2024-05-01)

主引用文献

Wei, H.,Wang, L.,Ren, X.,Yu, W.,Lin, J.,Jin, C.,Xia, B.
Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
Febs Lett., 589:1179-1186, 2015

PubMed Abstract: H-REV107-like family proteins TIG3 and H-REV107 are class II tumor suppressors. Here we report that the C-terminal domains (CTDs) of TIG3 and H-REV107 can induce HeLa cell death independently. The N-terminal domain (NTD) of TIG3 enhances the cell death inducing ability of CTD, while NTD of H-REV107 plays an inhibitory role. The solution structure of TIG3 NTD is very similar to that of H-REV107 in overall fold. However, the CTD binding regions on NTD are different between TIG3 and H-REV107, which may explain their functional difference. As a result, the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.

PubMed: 25871522
DOI: 10.1016/j.febslet.2015.04.002

実験手法

SOLUTION NMR