2MU8

Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum

2MU8 の概要

• エントリーDOI: 10.2210/pdb2mu8/pdb
• 関連するPDBエントリー: 2MU7
• NMR情報: BMRB: 25202
• 分子名称: MSP-2 peptide (1 entity in total)
• 機能のキーワード: merozoite surface protein 2, classic beta-turn, cell invasion
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2397.64

構造登録者

Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R. (登録日: 2014-09-04, 公開日: 2014-11-12, 最終更新日: 2024-05-15)

主引用文献

Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R.
Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective.
J.Med.Chem., 46:2250-2253, 2003

PubMed Abstract: The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system.

PubMed: 12747797
DOI: 10.1021/jm020440w

実験手法

SOLUTION NMR