2MQU

Spatial structure of Hm-3, a membrane-active spider toxin affecting sodium channels

Summary for 2MQU

Entry DOI	10.2210/pdb2mqu/pdb
NMR Information	BMRB: 25050
Descriptor	Neurotoxin Hm-3 (1 entity in total)
Functional Keywords	spider toxins, voltage-gated sodium channels, gating modifiers, inhibitor cystine knot, ick, channel activation, toxin
Biological source	Heriaeus melloteei (Crab spider)
Total number of polymer chains	1
Total formula weight	3919.71
Authors	Myshkin, M.Y.,Shenkarev, Z.O.,Paramonov, A.S.,Berkut, A.A.,Grishin, E.V.,Vassilevski, A.A. (deposition date: 2014-06-27, release date: 2014-11-05, Last modification date: 2023-06-14)
Primary citation	Berkut, A.A.,Peigneur, S.,Myshkin, M.Y.,Paramonov, A.S.,Lyukmanova, E.N.,Arseniev, A.S.,Grishin, E.V.,Tytgat, J.,Shenkarev, Z.O.,Vassilevski, A.A. Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae. J. Biol. Chem., 290:492-504, 2015 Cited by PubMed: 25352595 DOI: 10.1074/jbc.M114.595678 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation