2MQU

Spatial structure of Hm-3, a membrane-active spider toxin affecting sodium channels

2MQU の概要

• エントリーDOI: 10.2210/pdb2mqu/pdb
• NMR情報: BMRB: 25050
• 分子名称: Neurotoxin Hm-3 (1 entity in total)
• 機能のキーワード: spider toxins, voltage-gated sodium channels, gating modifiers, inhibitor cystine knot, ick, channel activation, toxin
• 由来する生物種: Heriaeus melloteei (Crab spider)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3919.71

構造登録者

Myshkin, M.Y.,Shenkarev, Z.O.,Paramonov, A.S.,Berkut, A.A.,Grishin, E.V.,Vassilevski, A.A. (登録日: 2014-06-27, 公開日: 2014-11-05, 最終更新日: 2023-06-14)

• 主引用文献: Berkut, A.A.,Peigneur, S.,Myshkin, M.Y.,Paramonov, A.S.,Lyukmanova, E.N.,Arseniev, A.S.,Grishin, E.V.,Tytgat, J.,Shenkarev, Z.O.,Vassilevski, A.A.; Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae.; J. Biol. Chem., 290:492-504, 2015; PubMed: 25352595; DOI: 10.1074/jbc.M114.595678

実験手法

SOLUTION NMR