2MPQ

Solution structure of the sodium channel toxin Hd1a

2MPQ の概要

• エントリーDOI: 10.2210/pdb2mpq/pdb
• NMR情報: BMRB: 19998
• 分子名称: Hd1a (1 entity in total)
• 機能のキーワード: spider toxin, disulfide-rich peptide, sodium channel, knottin, inhibitor cystine knot, toxin
• 由来する生物種: Haplopelma doriae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3891.48

構造登録者

Klint, J.K.,Mobli, M.,King, G.F. (登録日: 2014-06-01, 公開日: 2015-03-25, 最終更新日: 2024-11-27)

主引用文献

Klint, J.K.,Smith, J.J.,Vetter, I.,Rupasinghe, D.B.,Er, S.Y.,Senff, S.,Herzig, V.,Mobli, M.,Lewis, R.J.,Bosmans, F.,King, G.F.
Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Br.J.Pharmacol., 172:2445-2458, 2015

PubMed Abstract: Chronic pain is a serious worldwide health issue, with current analgesics having limited efficacy and dose-limiting side effects. Humans with loss-of-function mutations in the voltage-gated sodium channel NaV 1.7 (hNaV 1.7) are indifferent to pain, making hNaV 1.7 a promising target for analgesic development. Since spider venoms are replete with NaV channel modulators, we examined their potential as a source of hNaV 1.7 inhibitors.

PubMed: 25754331
DOI: 10.1111/bph.13081

実験手法

SOLUTION NMR