2MMT
Lasso peptide-based integrin inhibitor: Microcin J25 variant with RGDF substitution of Gly12-Ile13-Gly14-Thr15
Summary for 2MMT
Entry DOI | 10.2210/pdb2mmt/pdb |
NMR Information | BMRB: 19865 |
Descriptor | Microcin J25 RGDF mutant (1 entity in total) |
Functional Keywords | lasso peptide, epitope grafting, integrin inhibitor, drug design, molecular scaffolds, molecular dynamics, antibiotic |
Biological source | Escherichia coli |
Cellular location | Secreted: Q9X2V7 |
Total number of polymer chains | 1 |
Total formula weight | 2274.49 |
Authors | Hegemann, J.D.,Zimmermann, M.,Knappe, T.A.,Xie, X.,Marahiel, M.A. (deposition date: 2014-03-18, release date: 2014-07-02, Last modification date: 2014-07-23) |
Primary citation | Hegemann, J.D.,De Simone, M.,Zimmermann, M.,Knappe, T.A.,Xie, X.,Di Leva, F.S.,Marinelli, L.,Novellino, E.,Zahler, S.,Kessler, H.,Marahiel, M.A. Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. J.Med.Chem., 57:5829-5834, 2014 Cited by PubMed: 24949551DOI: 10.1021/jm5004478 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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