2MMK

Y41 and T47 phosphorylation of the Mengovirus Leader Protein: NMR Studies of the Phosphorylation of the Mengovirus Leader Protein Reveal Stabilization of Intermolecular Domain Interactions

2MMK の概要

• エントリーDOI: 10.2210/pdb2mmk/pdb
• 関連するPDBエントリー: 2MMG 2MMH 2MMI 2MML
• NMR情報: BMRB: 19857
• 分子名称: Leader protein, ZINC ION (2 entities in total)
• 機能のキーワード: animal viruses, positive-strand rna viruses, cardioviruses, leader, protein phosphorylation, casein kinase 2, spleen tyrosine kinase, viral protein
• 由来する生物種: Mengo virus
• 細胞内の位置: Protein 2A: Host nucleus . Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B: Virion . Protease 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P12296
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8487.41

構造登録者

Bacot-Davis, V.R.,Porter, F.W.,Palmenberg, A.C. (登録日: 2014-03-15, 公開日: 2014-10-15, 最終更新日: 2023-06-14)

• 主引用文献: Bacot-Davis, V.R.,Ciomperlik, J.J.,Basta, H.A.,Cornilescu, C.C.,Palmenberg, A.C.; Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase.; Proc.Natl.Acad.Sci.USA, 111:15792-15797, 2014; PubMed: 25331866; DOI: 10.1073/pnas.1411098111

実験手法

SOLUTION NMR