2MLP

MICROCIN LEADER PEPTIDE FROM E. COLI, NMR, 25 STRUCTURES

2MLP の概要

• エントリーDOI: 10.2210/pdb2mlp/pdb
• 分子名称: MCBA PROPEPTIDE (1 entity in total)
• 機能のキーワード: leader peptide, propeptide, antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2776.26

構造登録者

Kim, S.,Sinha Roy, R.,Walsh, C.T.,Baleja, J.D. (登録日: 1998-01-21, 公開日: 1998-07-22, 最終更新日: 2024-10-23)

主引用文献

Roy, R.S.,Kim, S.,Baleja, J.D.,Walsh, C.T.
Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26.
Chem.Biol., 5:217-228, 1998

PubMed Abstract: The peptide antibiotic microcin B17 (MccB17) contains oxazole and thiazole heterocycles formed by the post-translational modification of four cysteine and four serine residues. An amino-terminal propeptide targets the 69 amino acid precursor of MccB17 (preproMccB17) to the heterocyclization enzyme MccB17 synthetase. The mode of synthetase recognition has been unclear, because there has been limited structural information available on the MccB17 propeptide to date.

PubMed: 9545435
DOI: 10.1016/S1074-5521(98)90635-4

実験手法

SOLUTION NMR