2MGT

Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with Alzheimer's disease pathogenic English mutation H6R

2MGT の概要

• エントリーDOI: 10.2210/pdb2mgt/pdb
• NMR情報: BMRB: 19602
• 分子名称: Amyloid beta A4 protein, ZINC ION (2 entities in total)
• 機能のキーワード: alzheimer's disease, human amyloid -peptide, zinc binding, protein fibril, metal binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4071.69

構造登録者

Polshakov, V.,Istrate, A.,Kozin, S. (登録日: 2013-11-06, 公開日: 2014-11-12, 最終更新日: 2020-01-01)

• 主引用文献: Istrate, A.N.,Kozin, S.A.,Zhokhov, S.S.,Mantsyzov, A.B.,Kechko, O.I.,Pastore, A.,Makarov, A.A.,Polshakov, V.I.; Interplay of histidine residues of the Alzheimer's disease A beta peptide governs its Zn-induced oligomerization.; Sci Rep, 6:21734-21734, 2016; PubMed: 26898943; DOI: 10.1038/srep21734

実験手法

SOLUTION NMR