2MG8
Solution structure of TFF1 Estrogen Response Element complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)
Summary for 2MG8
Entry DOI | 10.2210/pdb2mg8/pdb |
Related | 1X95 |
NMR Information | BMRB: 19592 |
Descriptor | 5'-D(*AP*GP*GP*TP*CP*AP*CP*GP*GP*TP*GP*GP*CP*CP*A)-3', 5'-D(*TP*GP*GP*CP*CP*AP*CP*CP*GP*TP*GP*AP*CP*CP*T)-3', 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM (3 entities in total) |
Functional Keywords | breast cancer drug, dna bis-intercalation, ere-targeting small molecule anticancer drug, dna |
Total number of polymer chains | 2 |
Total formula weight | 10362.39 |
Authors | |
Primary citation | Lin, C.,Mathad, R.I.,Zhang, Z.,Sidell, N.,Yang, D. Solution structure of a 2:1 complex of anticancer drug XR5944 with TFF1 estrogen response element: insights into DNA recognition by a bis-intercalator. Nucleic Acids Res., 42:6012-6024, 2014 Cited by PubMed: 24711371DOI: 10.1093/nar/gku219 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report