2MFM

Solution structure of the C-terminally encoded peptide of the plant parasitic nematode Meloidogyne hapla - CEP11

2MFM の概要

• エントリーDOI: 10.2210/pdb2mfm/pdb
• 関連するPDBエントリー: 2MFO
• NMR情報: BMRB: 19555
• 分子名称: CEP11 (1 entity in total)
• 機能のキーワード: cep, meloidogyne, root-knot nematode, cle, hormone
• 由来する生物種: Meloidogyne hapla
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1522.64

構造登録者

Bobay, B.G.,DiGennaro, P.,Bird, D.M. (登録日: 2013-10-14, 公開日: 2013-12-11, 最終更新日: 2025-03-26)

主引用文献

Bobay, B.G.,Digennaro, P.,Scholl, E.,Imin, N.,Djordjevic, M.A.,McK Bird, D.
Solution NMR studies of the plant peptide hormone CEP inform function.
Febs Lett., 587:3979-3985, 2013

PubMed Abstract: The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space.

PubMed: 24211833
DOI: 10.1016/j.febslet.2013.10.033

実験手法

SOLUTION NMR