2MBF

Solution structure of the forkhead domain of Brugia malayi DAF-16a

2MBF の概要

• エントリーDOI: 10.2210/pdb2mbf/pdb
• NMR情報: BMRB: 19398
• 分子名称: Fork head domain containing protein (1 entity in total)
• 機能のキーワード: forkhead, foxo, foxo3a, winged helix, insulin/igf-1 signaling, filarial parasites, transcription
• 由来する生物種: Brugia malayi (agent of lymphatic filariasis)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11672.98

構造登録者

Veldkamp, C.T.,Peterson, F.C.,Casper, S.K.,Schoeller, S.J. (登録日: 2013-07-30, 公開日: 2013-09-11, 最終更新日: 2024-05-15)

主引用文献

Casper, S.K.,Schoeller, S.J.,Zgoba, D.M.,Phillips, A.J.,Morien, T.J.,Chaffee, G.R.,Sackett, P.C.,Peterson, F.C.,Crossgrove, K.,Veldkamp, C.T.
The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.
Proteins, 82:3490-3496, 2014

PubMed Abstract: Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins.

PubMed: 25297652
DOI: 10.1002/prot.24701

実験手法

SOLUTION NMR