2MB3

Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative

Summary for 2MB3

• Entry DOI: 10.2210/pdb2mb3/pdb
• NMR Information: BMRB: 19387
• Descriptor: DNA_(5'-D(*TP*TP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*A)-3'), (12S,27S)-12,27-bis(4-aminobutyl)-4,30-dimethyl-3,7,14,18,22,29-hexaoxa-11,26,31,32,33,34,35,36-octaazaheptacyclo[26.2. 1.1~2,5~.1~6,9~.1~13,16~.1~17,20~.1~21,24~]hexatriaconta-1(30),2(36),4,6(35),8,13(34),15,17(33),19,21(32),23,28(31)-dode caene-10,25-dione (2 entities in total)
• Functional Keywords: intramolecular g-quadruplex, human telomere, anticancer targets, macrocyclic hexaoxazole, telomestatin derivative, dna-dna inhibitor complex, dna/dna inhibitor
• Total number of polymer chains: 1
• Total formula weight: 8278.56

Authors

Chung, W.J.,Heddi, B.,Tera, M.,Iida, K.,Nagasawa, K.,Phan, A.T. (deposition date: 2013-07-24, release date: 2013-08-28, Last modification date: 2023-06-14)

• Primary citation: Chung, W.J.,Heddi, B.,Tera, M.,Iida, K.,Nagasawa, K.,Phan, A.T.; Solution structure of an intramolecular (3 + 1) human telomeric g-quadruplex bound to a telomestatin derivative.; J.Am.Chem.Soc., 135:13495-13501, 2013; PubMed: 23909929; DOI: 10.1021/ja405843r

Experimental method

SOLUTION NMR