2M86
Solution structure of Hdm2 with engineered cyclotide
Summary for 2M86
Entry DOI | 10.2210/pdb2m86/pdb |
NMR Information | BMRB: 19230 |
Descriptor | MCo-PMI, E3 ubiquitin-protein ligase Mdm2 (2 entities in total) |
Functional Keywords | hdm2 oncoprotein, mcoti-i cyclotide, p53 tumor suppressor, protein binding-signaling protein complex, protein binding/signaling protein |
Biological source | synthetic construct More |
Cellular location | Nucleus, nucleoplasm: 2M86 |
Total number of polymer chains | 2 |
Total formula weight | 19997.72 |
Authors | Majumder, S.,Ji, Y.,Millard, M.,Borra, R.,Bi, T.,Elnagar, A.Y.,Neamati, N.,Camarero, J.A. (deposition date: 2013-05-07, release date: 2013-07-31, Last modification date: 2023-06-14) |
Primary citation | Ji, Y.,Majumder, S.,Millard, M.,Borra, R.,Bi, T.,Elnagar, A.Y.,Neamati, N.,Shekhtman, A.,Camarero, J.A. In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide. J.Am.Chem.Soc., 135:11623-11633, 2013 Cited by PubMed: 23848581DOI: 10.1021/ja405108p PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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