2M5E

Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2

Summary for 2M5E

• Entry DOI: 10.2210/pdb2m5e/pdb
• Related: 1EXR 2KXW
• NMR Information: BMRB: 19050
• Descriptor: Calmodulin, Sodium channel protein type 2 subunit alpha, CALCIUM ION (3 entities in total)
• Functional Keywords: calcium binding protein, nav1.2, ion channel gating, iq motif, metal binding, sodium channels, metal transport, voltage dependent, voltage gated, calcium binding protein-metal transport complex, neuronal peptides, ef-hand, calcium-binding protein-metal transport complex, calcium-binding protein/metal transport
• Biological source: Paramecium tetraurelia; More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P04775
• Total number of polymer chains: 2
• Total formula weight: 11866.56

Authors

Fowler, C.A.,Feldkamp, M.D.,Yu, L.,Shea, M.A. (deposition date: 2013-02-21, release date: 2014-07-23, Last modification date: 2023-06-14)

• Primary citation: Hovey, L.,Fowler, C.A.,Mahling, R.,Lin, Z.,Miller, M.S.,Marx, D.C.,Yoder, J.B.,Kim, E.H.,Tefft, K.M.,Waite, B.C.,Feldkamp, M.D.,Yu, L.,Shea, M.A.; Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2.; Biophys. Chem., 224:1-19, 2017; PubMed: 28343066; DOI: 10.1016/j.bpc.2017.02.006

Experimental method

SOLUTION NMR