2M5E

Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2

2M5E の概要

• エントリーDOI: 10.2210/pdb2m5e/pdb
• 関連するPDBエントリー: 1EXR 2KXW
• NMR情報: BMRB: 19050
• 分子名称: Calmodulin, Sodium channel protein type 2 subunit alpha, CALCIUM ION (3 entities in total)
• 機能のキーワード: calcium binding protein, nav1.2, ion channel gating, iq motif, metal binding, sodium channels, metal transport, voltage dependent, voltage gated, calcium binding protein-metal transport complex, neuronal peptides, ef-hand, calcium-binding protein-metal transport complex, calcium-binding protein/metal transport
• 由来する生物種: Paramecium tetraurelia; 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P04775
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 11866.56

構造登録者

Fowler, C.A.,Feldkamp, M.D.,Yu, L.,Shea, M.A. (登録日: 2013-02-21, 公開日: 2014-07-23, 最終更新日: 2024-05-15)

• 主引用文献: Hovey, L.,Fowler, C.A.,Mahling, R.,Lin, Z.,Miller, M.S.,Marx, D.C.,Yoder, J.B.,Kim, E.H.,Tefft, K.M.,Waite, B.C.,Feldkamp, M.D.,Yu, L.,Shea, M.A.; Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2.; Biophys. Chem., 224:1-19, 2017; PubMed: 28343066; DOI: 10.1016/j.bpc.2017.02.006

実験手法

SOLUTION NMR