2M2N
Structure of [L-HisB24] insulin analogue at pH 8.0
Summary for 2M2N
Entry DOI | 10.2210/pdb2m2n/pdb |
Related | 2M2M 2M2O 2M2P |
NMR Information | BMRB: 18923 |
Descriptor | Insulin A chain, Insulin B chain (2 entities in total) |
Functional Keywords | insulin, hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 2 |
Total formula weight | 5808.62 |
Authors | Zakova, L.,Veverka, V.,Jiracek, J. (deposition date: 2012-12-29, release date: 2013-03-06, Last modification date: 2013-06-05) |
Primary citation | Kletvikova, E.,Veverka, V.,Lepsik, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M. Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288:10230-10240, 2013 Cited by PubMed: 23447530DOI: 10.1074/jbc.M112.448050 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report