2M0P

Solution structure of the tenth complement type repeat of human megalin

2M0P の概要

• エントリーDOI: 10.2210/pdb2m0p/pdb
• 関連するPDBエントリー: 2FYJ 2i1p
• NMR情報: BMRB: 18816
• 分子名称: Low-density lipoprotein receptor-related protein 2, CALCIUM ION (2 entities in total)
• 機能のキーワード: complement type repeat, receptor, megalin, ldl receptor family, lrp2, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P98164
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 5914.24

構造登録者

Dagil, R.,Kragelund, B. (登録日: 2012-11-01, 公開日: 2013-01-09, 最終更新日: 2023-06-14)

• 主引用文献: Dagil, R.,O'Shea, C.,Nykjar, A.,Bonvin, A.M.,Kragelund, B.B.; Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.; J.Biol.Chem., 288:4424-4435, 2013; PubMed: 23275343; DOI: 10.1074/jbc.M112.434159

実験手法

SOLUTION NMR