2M0B
Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles
Summary for 2M0B
| Entry DOI | 10.2210/pdb2m0b/pdb |
| NMR Information | BMRB: 18804 |
| Descriptor | Epidermal growth factor receptor (1 entity in total) |
| Functional Keywords | transmembrane domain, erbb1, receptor, dimerization, tyrosine kinase, membrane protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 9467.70 |
| Authors | Lesovoy, D.M.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Arseniev, A.S. (deposition date: 2012-10-24, release date: 2013-10-30, Last modification date: 2019-06-26) |
| Primary citation | Bocharov, E.V.,Lesovoy, D.M.,Pavlov, K.V.,Pustovalova, Y.E.,Bocharova, O.V.,Arseniev, A.S. Alternative packing of EGFR transmembrane domain suggests that protein-lipid interactions underlie signal conduction across membrane. Biochim. Biophys. Acta, 1858:1254-1261, 2016 Cited by PubMed: 26903218DOI: 10.1016/j.bbamem.2016.02.023 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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