2M0B

Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles

2M0B の概要

• エントリーDOI: 10.2210/pdb2m0b/pdb
• NMR情報: BMRB: 18804
• 分子名称: Epidermal growth factor receptor (1 entity in total)
• 機能のキーワード: transmembrane domain, erbb1, receptor, dimerization, tyrosine kinase, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 9467.70

構造登録者

Lesovoy, D.M.,Bocharov, E.V.,Pustovalova, Y.E.,Bocharova, O.V.,Arseniev, A.S. (登録日: 2012-10-24, 公開日: 2013-10-30, 最終更新日: 2024-05-01)

• 主引用文献: Bocharov, E.V.,Lesovoy, D.M.,Pavlov, K.V.,Pustovalova, Y.E.,Bocharova, O.V.,Arseniev, A.S.; Alternative packing of EGFR transmembrane domain suggests that protein-lipid interactions underlie signal conduction across membrane.; Biochim. Biophys. Acta, 1858:1254-1261, 2016; PubMed: 26903218; DOI: 10.1016/j.bbamem.2016.02.023

実験手法

SOLUTION NMR