2LU1

pfsub2 solution NMR structure

Summary for 2LU1

• Entry DOI: 10.2210/pdb2lu1/pdb
• NMR Information: BMRB: 18504
• Descriptor: Subtilase (1 entity in total)
• Functional Keywords: sub2 inhibitor prodomain, hydrolase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 1
• Total formula weight: 17721.33

Authors

He, Y.,Chen, Y.,Ruan, B.,O'Brochta, D.,Bryan, P.,Orban, J. (deposition date: 2012-06-06, release date: 2012-10-03, Last modification date: 2024-05-01)

Primary citation

He, Y.,Chen, Y.,Oganesyan, N.,Ruan, B.,O'Brochta, D.,Bryan, P.N.,Orban, J.
Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.
Proteins, 80:2810-2817, 2012

PubMed Abstract: Plasmodium subtilisin 2 (Sub2) is a multidomain protein that plays an important role in malaria infection. Here, we describe the solution NMR structure of a conserved region of the inhibitory prodomain of Sub2 from Plasmodium falciparum, termed prosub2. Despite the absence of any detectable sequence homology, the protozoan prosub2 has structural similarity to bacterial and mammalian subtilisin-like prodomains. Comparison with the three-dimensional structures of these other prodomains suggests a likely binding interface with the catalytic domain of Sub2 and provides insights into the locations of primary and secondary processing sites in Plasmodium prodomains.

PubMed: 23011838
DOI: 10.1002/prot.24187

Experimental method

SOLUTION NMR