2LOD

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops

2LOD の概要

• エントリーDOI: 10.2210/pdb2lod/pdb
• NMR情報: BMRB: 18209
• 分子名称: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*GP*GP*GP*GP*AP*CP*GP*GP*G)-3') (1 entity in total)
• 機能のキーワード: g-quadruplex, dna, loops
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6972.49

構造登録者

Marusic, M.,Sket, P.,Bauer, L.,Viglasky, V.,Plavec, J. (登録日: 2012-01-23, 公開日: 2012-05-30, 最終更新日: 2024-05-01)

主引用文献

Marusic, M.,Sket, P.,Bauer, L.,Viglasky, V.,Plavec, J.
Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops.
Nucleic Acids Res., 40:6946-6956, 2012

PubMed Abstract: We herein report on the formation and high-resolution NMR solution-state structure determination of a G-quadruplex adopted by d[G(3)ATG(3)ACACAG(4)ACG(3)] comprised of four G-tracts with the third one consisting of four guanines that are intervened with non-G streches of different lengths. A single intramolecular antiparallel (3+1) G-quadruplex exhibits three stacked G-quartets connected with propeller, diagonal and edgewise loops of different lengths. The propeller and edgewise loops are well structured, whereas the longer diagonal loop is more flexible. To the best of our knowledge, this is the first high-resolution G-quadruplex structure where all of the three main loop types are present.

PubMed: 22532609
DOI: 10.1093/nar/gks329

実験手法

SOLUTION NMR