2LF1

Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures

2LF1 の概要

• エントリーDOI: 10.2210/pdb2lf1/pdb
• 関連するPDBエントリー: 1LUD 2HM9 2L28
• NMR情報: BMRB: 17311
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (2 entities in total)
• 機能のキーワード: oxidoreductase, dhfr, positive cooperativity, protein-ligand interactions
• 由来する生物種: Lactobacillus casei
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19077.01

構造登録者

Polshakov, V.,Feeney, J.,Birdsall, B.,Kovalevskaya, N. (登録日: 2011-06-28, 公開日: 2011-12-21, 最終更新日: 2024-05-01)

• 主引用文献: Feeney, J.,Birdsall, B.,Kovalevskaya, N.V.,Smurnyy, Y.D.,Navarro Peran, E.M.,Polshakov, V.I.; NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions; Biochemistry, 50:3609-3620, 2011; PubMed: 21410224

実験手法

SOLUTION NMR