2LCT

Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide

2LCT の概要

• エントリーDOI: 10.2210/pdb2lct/pdb
• NMR情報: BMRB: 17632
• 分子名称: Proto-oncogene vav, Tyrosine-protein kinase SYK (2 entities in total)
• 機能のキーワード: phosphopeptide, syk kinase, tyrosine kinase, protein-peptide complex, phosphorylated peptide, phosphotyrosine binding domain, b cell signaling protein, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane (Probable): P48025
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14009.60

構造登録者

Chen, C.,Gorenstein, N.,Post, C. (登録日: 2011-05-09, 公開日: 2011-06-01, 最終更新日: 2023-06-14)

• 主引用文献: Chen, C.H.,Martin, V.A.,Gorenstein, N.M.,Geahlen, R.L.,Post, C.B.; Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.; Mol.Cell.Biol., 31:2984-2996, 2011; PubMed: 21606197; DOI: 10.1128/MCB.05043-11

実験手法

SOLUTION NMR