2L24

Antimicrobial peptide

2L24 の概要

• エントリーDOI: 10.2210/pdb2l24/pdb
• 分子名称: Hemagglutinin (1 entity in total)
• 機能のキーワード: antimicrobial peptide, design, hemagglutinin, antimicrobial protein
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1448.75

構造登録者

Zhu, S.,Aumelas, A.,Gao, B. (登録日: 2010-08-10, 公開日: 2011-06-22, 最終更新日: 2024-10-30)

主引用文献

Zhu, S.,Aumelas, A.,Gao, B.
Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin.
J.Med.Chem., 54:1091-1095, 2011

PubMed Abstract: Antimicrobial activity and solution structures of four 13-amino acid peptides derived from the fusion domain of viral hemagglutinin proteins are presented. The results show that carboxyl-terminal amidation is a key factor to switch a viral fusion domain-derived sequence into an antimicrobial peptide. Optimization of amphiphilic balance on the amidated analogue largely improves efficacy and enlarges antimicrobial spectra of these peptides. Our work indicates that viral fusion domains have potential to be engineered into potent antimicrobial peptides.

PubMed: 21222457
DOI: 10.1021/jm1010463

実験手法

SOLUTION NMR