2KYA

Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34

2KYA の概要

• エントリーDOI: 10.2210/pdb2kya/pdb
• NMR情報: BMRB: 16943
• 分子名称: Patellamide protein (1 entity in total)
• 機能のキーワード: cyclic peptides, pate, patellamides, prochloron, ribosomal peptide synthetase, unknown function
• 由来する生物種: Prochloron didemni
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3709.25

構造登録者

Houssen, W.E.,Wright, S.H.,Kalverda, A.P.,Thompson, G.S.,Kelly, S.M.,Jaspars, M. (登録日: 2010-05-21, 公開日: 2010-09-01, 最終更新日: 2024-05-01)

主引用文献

Houssen, W.E.,Wright, S.H.,Kalverda, A.P.,Thompson, G.S.,Kelly, S.M.,Jaspars, M.
Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE(1-34).
Chembiochem, 11:1867-1873, 2010

PubMed Abstract: The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an alpha-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes.

PubMed: 20715266
DOI: 10.1002/cbic.201000305

実験手法

SOLUTION NMR