2KVD

Mesencephalic astrocyte-derived neurotrophic factor (MANF)

2KVD の概要

• エントリーDOI: 10.2210/pdb2kvd/pdb
• 関連するPDBエントリー: 2KVE
• NMR情報: BMRB: 16775
• 分子名称: Mesencephalic astrocyte-derived neurotrophic factor (1 entity in total)
• 機能のキーワード: disulfide bond, glycoprotein, growth factor, secreted, sialic acid, unfolded protein response, hormone
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P55145
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18339.27

構造登録者

Hellman, M.H.,Peranen, J.,Saarma, M.,Permi, P. (登録日: 2010-03-12, 公開日: 2010-11-03, 最終更新日: 2024-11-20)

主引用文献

Hellman, M.H.,Arumae, U.,Yu, L.-Y.,Lindholm, P.,Peranen, J.,Saarma, M.,Permi, P.
Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons
J.Biol.Chem., 286:2675-2680, 2011

PubMed Abstract: Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well known inhibitor of proapoptotic Bax (Bcl-2-associated X protein). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.

PubMed: 21047780
DOI: 10.1074/jbc.M110.146738

実験手法

SOLUTION NMR