2LPB

Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15

Replaces:  2KO4

Summary for 2LPB

• Entry DOI: 10.2210/pdb2lpb/pdb
• NMR Information: BMRB: 18244
• Descriptor: Mediator of RNA polymerase II transcription subunit 15, General control protein GCN4 (2 entities in total)
• Functional Keywords: mediator, activator, co-activator, transcription, nucleus, phosphoprotein, transcription regulation, amino acid biosynthesis, dna-binding
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Nucleus: P19659 P03069
• Total number of polymer chains: 2
• Total formula weight: 13473.12

Authors

Brzovic, P.S.,Heikaus, C.C.,Kisselev, L.,Vernon, R.,Herbig, E.,Pacheco, D.,Warfield, L.,Littlefield, P.,Baker, D.,Klevit, R.E.,Hahn, S. (deposition date: 2012-02-07, release date: 2012-02-22, Last modification date: 2024-05-01)

• Primary citation: Brzovic, P.S.,Heikaus, C.C.,Kisselev, L.,Vernon, R.,Herbig, E.,Pacheco, D.,Warfield, L.,Littlefield, P.,Baker, D.,Klevit, R.E.,Hahn, S.; The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.; Mol.Cell, 44:942-953, 2011; PubMed: 22195967; DOI: 10.1016/j.molcel.2011.11.008

Experimental method

SOLUTION NMR