2KLR

Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers

2KLR の概要

• エントリーDOI: 10.2210/pdb2klr/pdb
• 分子名称: Alpha-crystallin B chain (1 entity in total)
• 機能のキーワード: protein, dimer, oligomer, heterogeneity, intermolecular interactions, chaperone, shsp, human, small heat-shock protein, cataract, desmin-related myopathy, disease mutation, eye lens protein, glycoprotein, methylation, oxidation, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P02511
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40383.86

構造登録者

Jehle, S.,Rajagopal, P.,Markovic, S.,Bardiaux, B.,Kuehne, R.,Higman, V.A.,Klevit, R.E.,van Rossum, B.,Oschkinat, H. (登録日: 2009-07-08, 公開日: 2010-07-07, 最終更新日: 2011-07-13)

• 主引用文献: Jehle, S.,Rajagopal, P.,Bardiaux, B.,Markovic, S.,Kuhne, R.,Stout, J.R.,Higman, V.A.,Klevit, R.E.,van Rossum, B.J.,Oschkinat, H.; Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers.; Nat.Struct.Mol.Biol., 17:1037-1042, 2010; PubMed: 20802487; DOI: 10.1038/nsmb.1891

実験手法

SOLID-STATE NMR