2KKA

Human telomere DNA two-tetrad quadruplex structure in K+ solution

Summary for 2KKA

• Entry DOI: 10.2210/pdb2kka/pdb
• Related: 2HY9 2JPZ
• NMR Information: BMRB: 16356
• Descriptor: 5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*IP*GP*GP*TP*TP*AP*GP*GP*GP*T)-3' (1 entity in total)
• Functional Keywords: human telomere g-quadruplex, dna
• Total number of polymer chains: 1
• Total formula weight: 7272.68

Authors

Zhang, Z.,Dai, J.,Yang, D. (deposition date: 2009-06-16, release date: 2009-12-15, Last modification date: 2024-05-01)

Primary citation

Zhang, Z.,Dai, J.,Veliath, E.,Jones, R.A.,Yang, D.
Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures.
Nucleic Acids Res., 38:1009-1021, 2010

PubMed Abstract: Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.

PubMed: 19946019
DOI: 10.1093/nar/gkp1029

Experimental method

SOLUTION NMR