2KI9

Human cannabinoid receptor-2 helix 6

2KI9 の概要

• エントリーDOI: 10.2210/pdb2ki9/pdb
• NMR情報: BMRB: 16268
• 分子名称: Cannabinoid receptor 2 (1 entity in total)
• 機能のキーワード: human cannabinoid receptor-2, gpcr, g-protein coupled receptor, membrane protein
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P34972
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3553.39

構造登録者

Deshmukh, L.,Vinogradova, O.,Tiburu, E.K.,Tyukhtenko, S.,Janero, D.R.,Makriyannis, A. (登録日: 2009-04-28, 公開日: 2009-05-12, 最終更新日: 2024-05-22)

主引用文献

Tiburu, E.K.,Tyukhtenko, S.,Deshmukh, L.,Vinogradova, O.,Janero, D.R.,Makriyannis, A.
Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.
Biochem.Biophys.Res.Commun., 384:243-248, 2009

PubMed Abstract: We detail the structure and dynamics of a synthetic peptide corresponding to transmembrane helix 6 (TMH6) of human cannabinoid receptor-2 (hCB2) in biomembrane-mimetic environments. The peptide's NMR structural biology is characterized by two alpha-helical domains bridged by a flexible, nonhelical hinge region containing a highly-conserved CWFP motif with an environmentally sensitive, Pro-based conformational switch. Buried within the peptide's flexible region, W(258) may hydrogen-bond with L(255) to help stabilize the Pro-kinked hCB2 TMH6 structure and position C(257) advantageously for interaction with agonist ligands. These characteristics of hCB2 TMH6 are potential structural features of ligand-induced hCB2 activation in vivo.

PubMed: 19397896
DOI: 10.1016/j.bbrc.2009.04.099

実験手法

SOLUTION NMR