2KGI

Solution structure of JARID1A C-terminal PHD finger in complex with H3(1-9)K4me3

2KGI の概要

• エントリーDOI: 10.2210/pdb2kgi/pdb
• NMR情報: BMRB: 16210
• 分子名称: Histone demethylase JARID1A, H3(1-9)K4me3, ZINC ION (3 entities in total)
• 機能のキーワード: phd finger, jarid1a, histone modification, leukemia, alternative splicing, chromatin regulator, developmental protein, dioxygenase, iron, metal-binding, nucleus, oxidoreductase, phosphoprotein, polymorphism, transcription, transcription regulation, zinc, zinc-finger, metal binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7038.64

構造登録者

Song, J.,Wang, Z.,Patel, D.J. (登録日: 2009-03-12, 公開日: 2009-05-05, 最終更新日: 2020-02-26)

• 主引用文献: Wang, G.G.,Song, J.,Wang, Z.,Dormann, H.L.,Casadio, F.,Li, H.,Luo, J.L.,Patel, D.J.,Allis, C.D.; Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.; Nature, 459:847-851, 2009; PubMed: 19430464; DOI: 10.1038/nature08036

実験手法

SOLUTION NMR