2KDR

Solution structure of HCV NS4B(227-254)

2KDR の概要

• エントリーDOI: 10.2210/pdb2kdr/pdb
• 関連するPDBエントリー: 2JXF
• NMR情報: BMRB: 16122
• 分子名称: Non-structural protein 4B (1 entity in total)
• 機能のキーワード: hcv, ns4b, 227-254 segment, membranous web, replication complex, membrane, transmembrane, rna-binding, palmitate, viral protein, membrane protein
• 由来する生物種: Hepatitis C virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3111.60

構造登録者

Montserret, R.,Penin, F. (登録日: 2009-01-15, 公開日: 2009-09-29, 最終更新日: 2024-05-15)

主引用文献

Gouttenoire, J.,Montserret, R.,Kennel, A.,Penin, F.,Moradpour, D.
An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association
J.Virol., 83:11378-11384, 2009

PubMed Abstract: Nonstructural protein 4B (NS4B) plays an essential role in the formation of the hepatitis C virus (HCV) replication complex. It is an integral membrane protein that has been only poorly characterized to date. It is believed to comprise a cytosolic N-terminal part, a central part harboring four transmembrane passages, and a cytosolic C-terminal part. Here, we describe an amphipathic alpha-helix at the C terminus of NS4B (amino acid residues 229 to 253) that mediates membrane association and is involved in the formation of a functional HCV replication complex.

PubMed: 19692468
DOI: 10.1128/JVI.01122-09

実験手法

SOLUTION NMR