2JXF
The solution structure of HCV NS4B(40-69)
Summary for 2JXF
| Entry DOI | 10.2210/pdb2jxf/pdb |
| NMR Information | BMRB: 15559 |
| Descriptor | Genome polyprotein (1 entity in total) |
| Functional Keywords | membrane associated segment, acetylation, apoptosis, atp-binding, capsid protein, cytoplasm, endoplasmic reticulum, envelope protein, fusion protein, glycoprotein, helicase, host-virus interaction, hydrolase, interferon antiviral system evasion, lipid droplet, lipoprotein, metal-binding, mitochondrion, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, oncogene, palmitate, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, sh3-binding, thiol protease, transcription, transcription regulation, transferase, transmembrane, ubl conjugation, viral nucleoprotein, virion, zinc, viral protein, membrane protein |
| Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958 |
| Total number of polymer chains | 1 |
| Total formula weight | 3601.12 |
| Authors | Montserret, R.,Penin, F. (deposition date: 2007-11-19, release date: 2008-11-25, Last modification date: 2022-03-16) |
| Primary citation | Gouttenoire, J.,Castet, V.,Montserret, R.,Arora, N.,Raussens, V.,Ruysschaert, J.-M.,Diesis, E.,Blum, H.E.,Penin, F.,Moradpour, D. Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B J.Virol., 83:6257-6268, 2009 Cited by PubMed: 19357161DOI: 10.1128/JVI.02663-08 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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