2KCE
BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY
Summary for 2KCE
Entry DOI | 10.2210/pdb2kce/pdb |
Descriptor | THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (4 entities in total) |
Functional Keywords | methyltransferase, reaction intermediate, antifolate, drug design |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A884 |
Total number of polymer chains | 2 |
Total formula weight | 62564.65 |
Authors | Rutenber, E.E.,Stroud, R.M. (deposition date: 1997-06-09, release date: 1997-11-19, Last modification date: 2024-06-05) |
Primary citation | Rutenber, E.E.,Stroud, R.M. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Structure, 4:1317-1324, 1996 Cited by PubMed: 8939755DOI: 10.1016/S0969-2126(96)00139-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report