NMR structure of the mDvl1 PDZ domain in complex with its inhibitor

Summary for 2KAW

Related1mc7 1l6o
DescriptorSegment polarity protein dishevelled homolog DVL-1, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid (2 entities in total)
Functional Keywordsinhibitor of protein-protein interactions, protein structure, pdz domain, wnt signaling, developmental protein, wnt signaling pathway, signaling protein
Biological sourceMus musculus (mouse)
Cellular locationCell membrane; Peripheral membrane protein; Cytoplasmic side P51141
Total number of polymer chains1
Total molecular weight9989.3
Lee, H.J.,Shao, Y.,Wang, N.X.,Shi, D.L.,Zheng, J.J. (deposition date: 2008-11-17, release date: 2009-09-15, Last modification date: 2011-07-13)
Primary citation
Lee, H.J.,Wang, N.X.,Shi, D.L.,Zheng, J.J.
Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
Angew.Chem.Int.Ed.Engl., 48:6448-6452, 2009
PubMed: 19637179 (PDB entries with the same primary citation)
DOI: 10.1002/anie.200902981
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers20.1%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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