2KAW

NMR structure of the mDvl1 PDZ domain in complex with its inhibitor

2KAW の概要

• エントリーDOI: 10.2210/pdb2kaw/pdb
• 関連するPDBエントリー: 1l6o 1mc7
• 分子名称: Segment polarity protein dishevelled homolog DVL-1, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid (2 entities in total)
• 機能のキーワード: inhibitor of protein-protein interactions, protein structure, pdz domain, wnt signaling, developmental protein, wnt signaling pathway, signaling protein
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cell membrane; Peripheral membrane protein; Cytoplasmic side: P51141
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9989.30

構造登録者

Lee, H.J.,Shao, Y.,Wang, N.X.,Shi, D.L.,Zheng, J.J. (登録日: 2008-11-17, 公開日: 2009-09-15, 最終更新日: 2011-07-13)

• 主引用文献: Lee, H.J.,Wang, N.X.,Shi, D.L.,Zheng, J.J.; Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.; Angew.Chem.Int.Ed.Engl., 48:6448-6452, 2009; PubMed: 19637179; DOI: 10.1002/anie.200902981

実験手法

SOLUTION NMR