2K8U

Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC

2K8U の概要

• エントリーDOI: 10.2210/pdb2k8u/pdb
• 関連するPDBエントリー: 2K8T
• 分子名称: 5'-D(*DGP*DCP*DTP*DAP*DGP*DCP*DGP*DAP*DGP*DTP*DCP*DC)-3', 5'-D(*DGP*DGP*DAP*DCP*DTP*DCP*DGP*DCP*DTP*DAP*DGP*DC)-3', (2S,5R)-5-pentyltetrahydrofuran-2-ol (3 entities in total)
• 機能のキーワード: hne-dg (6s, 8r, 11s), hne derived dg adduct, trans-4-hydroxynonenal, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7485.02

構造登録者

Huang, H.,Wang, H.,Qi, N.,Lloyd, R.S.,Rizzo, C.J.,Stone, M.P. (登録日: 2008-09-23, 公開日: 2008-11-04, 最終更新日: 2022-03-16)

• 主引用文献: Huang, H.,Wang, H.,Qi, N.,Lloyd, R.S.,Rizzo, C.J.,Stone, M.P.; The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence.; Biochemistry, 47:11457-11472, 2008; PubMed: 18847226; DOI: 10.1021/bi8011143

実験手法

SOLUTION NMR