2K2G

Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor

2K2G の概要

• エントリーDOI: 10.2210/pdb2k2g/pdb
• 分子名称: Macrophage metalloelastase, ZINC ION, N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine (3 entities in total)
• 機能のキーワード: macrophage elastase, matrix metalloproteinase, protein-ligand structure, catalytic domain, human gene, calcium, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P39900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18860.87

構造登録者

Markus, M.A.,Dwyer, B.,Wolfrom, S.,Li, J.,Li, W.,Malakian, K.,Wilhelm, J.,Tsao, D.H.H. (登録日: 2008-04-01, 公開日: 2008-05-20, 最終更新日: 2024-05-29)

• 主引用文献: Markus, M.A.,Dwyer, B.,Wolfrom, S.,Li, J.,Li, W.,Malakian, K.,Wilhelm, J.,Tsao, D.H.; Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor.; J.Biomol.Nmr, 41:55-60, 2008; PubMed: 18425585; DOI: 10.1007/s10858-008-9236-4

実験手法

SOLUTION NMR